{"id":192,"date":"2020-09-30T09:18:22","date_gmt":"2020-09-30T09:18:22","guid":{"rendered":"http:\/\/adultlch.gr\/?page_id=192"},"modified":"2025-02-04T09:12:54","modified_gmt":"2025-02-04T09:12:54","slug":"dimosiefseis","status":"publish","type":"page","link":"https:\/\/adultlch.gr\/index.php\/dimosiefseis\/","title":{"rendered":"\u0394\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03ad\u03bd\u03c4\u03c1\u03bf\u03c5"},"content":{"rendered":"\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39699236\/\">Approach to the Patient: From Endocrinopathy to the Diagnosis of a Histiocytic Disorder.<\/a><\/h6>\n\n\n\n<p><em>Makras P, Erickson D, Davidge-Pitts CJ, Diamond EL, Allen CE, McClain KL, Abeykoon JP, Go RS, Siwakoti K, Sotoudeh H, Ravindran A, Gruber LM, Goyal G. J Clin Endocrinol Metab. 2024 Dec 19:dgae827. doi: 10.1210\/clinem\/dgae827. Online ahead of print.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37073626\/\">Efficacy of denosumab monotherapy among adults with Langerhans cell histiocytosis: A prospective clinical trial.<\/a><\/h6>\n\n\n\n<p><em><em>Makras P, Yavropoulou MP, Chatziioannou SN, Anastasilakis AD, Georgakopoulou D, Tsoli M, Chatzelis E, Kaltsas G. Am J Hematol. 2023 Jul;98(7):E168-E171. doi: 10.1002\/ajh.26936.<\/em><\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35271698\/\">International expert consensus recommendations for the diagnosis and treatment of Langerhans cell histiocytosis in adults.<\/a><\/h6>\n\n\n\n<p><em>Goyal G, Tazi A, Go RS, Rech KL, Picarsic JL, Vassallo R, Young JR, Cox CW, Van Laar J, Hermiston ML, Cao XX, Makras P, Kaltsas G, Haroche J, Collin M, McClain KL, Diamond EL, Girschikofsky M. Blood. 2022 Apr 28;139(17):2601-2621.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35207181\/\">Adult Langerhans Cell Histiocytosis and the Skeleton.<\/a><\/h6>\n\n\n\n<p>G<em>eorgakopoulou D, Anastasilakis AD, Makras P. J Clin Med. 2022 Feb 9;11(4):909.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35139731\/\">Prevalence of the BRAF V600E mutation in Greek adults with Langerhans cell histiocytosis.<\/a><\/h6>\n\n\n\n<p><em>Stathi D, Yavropoulou MP, Allen CE, Abhyankar H, Scull B, Tsoli M, Andreakos E, Kaltsas G,&nbsp;Makras P.&nbsp;Pediatr Hematol Oncol. 2022 Feb 10:1-9.&nbsp;<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32618036\/\">The annual incidence of&nbsp;<strong>Langerhans<\/strong>&nbsp;cell histiocytosis among adults living in Greece.<\/a><\/h6>\n\n\n\n<p><em>Makras P, Stathi D, Yavropoulou M, Tsoli M, Kaltsas G.Pediatr Blood Cancer. 2020 Jul 2:e28422. doi: 10.1002\/pbc.28422<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29967185\/\">Bone metabolism in&nbsp;<strong>Langerhans<\/strong>&nbsp;cell histiocytosis.<\/a><\/h6>\n\n\n\n<p><em>Anastasilakis AD, Tsoli M, Kaltsas G,&nbsp;Makras P.Endocr Connect. 2018 Jul;7(7):R246-R253. doi: 10.1530\/EC-18-0186. Epub 2018 Jul 2<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28521873\/\">Low periostin levels in adult patients with&nbsp;<strong>Langerhans<\/strong>&nbsp;cell histiocytosis are independently associated with the disease activity.<\/a><\/h6>\n\n\n\n<p><em>Anastasilakis AD, Polyzos SA, Tsoli M, Papatheodorou A, Kokkoris P, Kaltsas G, Terpos E,&nbsp;Makras P.Metabolism. 2017 Jun;71:198-201. doi: 10.1016\/j.metabol.2017.03.017. Epub 2017 Apr 4.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28285639\/\">Denosumab for the treatment of adult multisystem&nbsp;<strong>Langerhans<\/strong>&nbsp;cell histiocytosis.<\/a><\/h6>\n\n\n\n<p><em>Makras P, Tsoli M, Anastasilakis AD, Thanou M, Kaltsas G.Metabolism. 2017 Apr;69:107-111. doi: 10.1016\/j.metabol.2017.01.004. Epub 2017 Jan 12.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27413525\/\">Bisphosphonates in&nbsp;<strong>Langerhans<\/strong>&nbsp;Cell Histiocytosis: An International Retrospective Case Series.<\/a><\/h6>\n\n\n\n<p><em>Chellapandian D,&nbsp;Makras P, Kaltsas G, van den Bos C, Naccache L, Rampal R, Carret AS, Weitzman S, Egeler RM, Abla O.Mediterr J Hematol Infect Dis. 2016 Jul 1;8(1):e2016033. doi: 10.4084\/MJHID.2016.033. eCollection 2016<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25552340\/\">Langerhans&nbsp;cell histiocytosis and pituitary function.<\/a><\/strong><\/h6>\n\n\n\n<p><em>Makras P, Kaltsas G.Endocrine. 2015 Apr;48(3):728-9. doi: 10.1007\/s12020-014-0497-2. Epub 2015 Jan 1.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25375981\/\">Rationale for the application of RANKL inhibition in the treatment of&nbsp;<strong>Langerhans<\/strong>&nbsp;cell histiocytosis.<\/a><\/h6>\n\n\n\n<p><em>Makras P, Salagianni M, Revelos K, Anastasilakis AD, Schini M, Tsoli M, Kaltsas G, Andreakos E.J Clin Endocrinol Metab. 2015 Feb;100(2):E282-6. doi: 10.1210\/jc.2014-2654. Epub 2014 Nov 6.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23672541\/\">Management of adult patients with&nbsp;<strong>Langerhans<\/strong>&nbsp;cell histiocytosis: recommendations from an expert panel on behalf of Euro-Histio-Net.<\/a><\/h6>\n\n\n\n<p><em>Girschikofsky M, Arico M, Castillo D, Chu A, Doberauer C, Fichter J, Haroche J, Kaltsas GA,&nbsp;Makras P, Marzano AV, de Menthon M, Micke O, Passoni E, Seegenschmiedt HM, Tazi A, McClain KL.Orphanet J Rare Dis. 2013 May 14;8:72. doi: 10.1186\/1750-1172-8-72<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23101752\/\">Cladribine therapy in adults with advanced&nbsp;<strong>Langerhans<\/strong>&nbsp;cell histiocytosis.<\/a><\/h6>\n\n\n\n<p><em>Schini M,&nbsp;Makras P, Kanakis G, Voulgarelis M, Kaltsas G.Leuk Lymphoma. 2013 Jul;54(7):1541-3. doi: 10.3109\/10428194.2012.744454. Epub 2012 Nov 26.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22278426\/\">Serum osteoprotegerin, RANKL, and Dkk-1 levels in adults with&nbsp;<strong>Langerhans<\/strong>&nbsp;cell histiocytosis.<\/a><\/h6>\n\n\n\n<p><em>Makras P, Polyzos SA, Anastasilakis AD, Terpos E, Kanakis G, Schini M, Papatheodorou A, Kaltsas GA.J Clin Endocrinol Metab. 2012 Apr;97(4):E618-21. doi: 10.1210\/jc.2011-2962. Epub 2012 Jan 25.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22215051\/\">Is serum IL-17A a useful systemic biomarker in patients with&nbsp;<strong>Langerhans<\/strong>&nbsp;cell histiocytosis?<\/a><\/h6>\n\n\n\n<p><em>Makras P, Polyzos SA, Anastasilakis AD, Terpos E, Papatheodorou A, Kaltsas GA.Mol Ther. 2012 Jan;20(1):6-7. doi: 10.1038\/mt.2011.239.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21625059\/\">Adult case of&nbsp;<strong>Langerhans<\/strong>&nbsp;cell histiocytosis with single site vertebral involvement.<\/a><\/h6>\n\n\n\n<p><em>Paxinos O, Delimpasis G,&nbsp;Makras P.,J Musculoskelet Neuronal Interact. 2011 Jun;11(2):212-4; quiz 214.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21548013\/\">Reduced bone mineral density in adult patients with&nbsp;<strong>Langerhans<\/strong>&nbsp;cell histiocytosis.<\/a><\/h6>\n\n\n\n<p><em>Makras P, Terpos E, Kanakis G, Papatheodorou A, Anastasilakis AD, Kokkoris P, Kaltsas GA.Pediatr Blood Cancer. 2012 May;58(5):819-22. doi: 10.1002\/pbc.23166. Epub 2011 May 5.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21279449\/\">Distinctive growth pattern in a patient with a delayed diagnosis of&nbsp;<strong>Langerhans<\/strong>&#8216; cell histiocytosis.<\/a><\/h6>\n\n\n\n<p><em>Anastasilakis AD, Kaltsas GA, Delimpasis G, Wilkens L, Kanakis G,&nbsp;Makras P. Pituitary. 2012 Dec;15 Suppl 1:S28-32. doi: 10.1007\/s11102-011-0291-6.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18160417\/\">Cardiovascular risk factors in adult patients with multisystem&nbsp;<strong>Langerhans<\/strong>-cell histiocytosis: evidence of glucose metabolism abnormalities.<\/a><\/h6>\n\n\n\n<p><em>Alexandraki KI,&nbsp;Makras P, Protogerou AD, Dimitriou K, Stathopoulou A, Papadogias DS, Voidonikola P, Piaditis G, Pittas A, Papamichael CM, Grossman AB, Kaltsas G.QJM. 2008 Jan;101(1):31-40. doi: 10.1093\/qjmed\/hcm118. Epub 2007 Dec 26.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30290476\/\">Systemic and endocrine manifestations of&nbsp;<strong>Langerhans<\/strong>&#8216; cell histiocytosis: current concepts in diagnosis and management.<\/a><\/h6>\n\n\n\n<p><em>Makras P, Piaditis G, Kaltsas GA.Expert Rev Endocrinol Metab. 2007 Nov;2(6):773-783. doi: 10.1586\/17446651.2.6.773.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17600725\/\">Endocrine manifestations in&nbsp;<strong>Langerhans<\/strong>&nbsp;cell histiocytosis.<\/a><\/h6>\n\n\n\n<p><em>Makras P, Alexandraki KI, Chrousos GP, Grossman AB, Kaltsas GA.Trends Endocrinol Metab. 2007 Aug;18(6):252-7. doi: 10.1016\/j.tem.2007.06.003. Epub 2007 Jun 27.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16982579\/\">Langerhans&#8217; cell histiocytosis in an adult patient manifested as recurrent skull lesions and Diabetes Insipidus.<\/a><\/strong><\/h6>\n\n\n\n<p><em>Makras P, Papadogias D, Samara C, Zetos A, Kaltsas G, Piaditis G, Chu AC.Hormones (Athens). 2004 Jan-Mar;3(1):59-64. doi: 10.14310\/horm.2002.11113.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16379033\/\">Spontaneous gonadotrophin deficiency recovery in an adult patient with&nbsp;<strong>Langerhans<\/strong>&nbsp;cell histiocytosis (LCH).<\/a><\/h6>\n\n\n\n<p><em>Makras P, Papadogias D, Kontogeorgos G, Piaditis G, Kaltsas GA.Pituitary. 2005;8(2):169-74. doi: 10.1007\/s11102-005-4537-z.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n\n<h6 class=\"wp-block-heading\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16292545\/\">Evolving radiological features of hypothalamo-pituitary lesions in adult patients with&nbsp;<strong>Langerhans<\/strong>&nbsp;cell histiocytosis (LCH).<\/a><\/h6>\n\n\n\n<p><em>Makras P, Samara C, Antoniou M, Zetos A, Papadogias D, Nikolakopoulou Z, Andreakos E, Toloumis G, Kontogeorgos G, Piaditis G, Kaltsas GA.Neuroradiology. 2006 Jan;48(1):37-44. doi: 10.1007\/s00234-005-0011-x. Epub 2005 Nov 15.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n","protected":false},"excerpt":{"rendered":"<p>Approach to the Patient: From Endocrinopathy to the Diagnosis of a Histiocytic Disorder. Makras P, Erickson D, Davidge-Pitts CJ, Diamond EL, Allen CE, McClain KL, Abeykoon JP, Go RS, Siwakoti K, Sotoudeh H, Ravindran A, Gruber LM, Goyal G. J Clin Endocrinol Metab. 2024 Dec 19:dgae827. doi: 10.1210\/clinem\/dgae827. Online ahead of print. Efficacy of denosumab [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-192","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u0394\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03ad\u03bd\u03c4\u03c1\u03bf\u03c5 - \u039a\u03ad\u03bd\u03c4\u03c1\u03bf \u0395\u03bc\u03c0\u03b5\u03b9\u03c1\u03bf\u03b3\u03bd\u03c9\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7\u03c2 \u0399\u03c3\u03c4\u03b9\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7\u03c2 \u03b5\u03ba \u039a\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd Langerhans<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/adultlch.gr\/index.php\/dimosiefseis\/\" \/>\n<meta property=\"og:locale\" content=\"el_GR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u0394\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03ad\u03bd\u03c4\u03c1\u03bf\u03c5 - \u039a\u03ad\u03bd\u03c4\u03c1\u03bf \u0395\u03bc\u03c0\u03b5\u03b9\u03c1\u03bf\u03b3\u03bd\u03c9\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7\u03c2 \u0399\u03c3\u03c4\u03b9\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7\u03c2 \u03b5\u03ba \u039a\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd Langerhans\" \/>\n<meta property=\"og:description\" content=\"Approach to the Patient: From Endocrinopathy to the Diagnosis of a Histiocytic Disorder. Makras P, Erickson D, Davidge-Pitts CJ, Diamond EL, Allen CE, McClain KL, Abeykoon JP, Go RS, Siwakoti K, Sotoudeh H, Ravindran A, Gruber LM, Goyal G. J Clin Endocrinol Metab. 2024 Dec 19:dgae827. doi: 10.1210\/clinem\/dgae827. Online ahead of print. 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